Benzodizapenes are the most widely used anxiolytic drug. They have largely replaced barbiturates and meprobamate in the treatment of Anxiety because they are safer and more effective. Alprazolam belongs to this class of drugs, it is used for the treatment of the anxiety symptoms of panic disorders.Present study deals with a brief overview of the comparative study of different brands of Alprazolam tablets according to Pharmacopeia (BP) & United States Pharmacopeia (USP) . for this reason.3 differen brands of Alprazolam 0.5 mg tablets have been evaluated using quality control test of thickness, hardness, weight variation and friability to assess that whether these 3 brands are pharmaceutically equivalent.