To explore whether medical instructions might improve dapoxetine efficacy for lifelong premature ejaculation (PE). All PE patients received dapoxetine 60 mg. Sixty patients (Group 1) were given the following instructions “Take one tablet two hours before sexual intercourse; dapoxetine will delay your ejaculation” and 64 patients (Group 2) were given the following instructions “Take one tablet two hours before sexual intercourse; do not try to delay or to hold back ejaculation because dapoxetine is doing it for you. Dapoxetine will delay/improve your ejaculation within 3 months from the first assumption”. Before, and during the course of dapoxetine assumption, the stopwatch-measured intravaginal ejaculatory latency time, the Clinical Global Impression of Change and the side effects were measured in both groups. Results: The baseline intravaginal ejaculatory latency time and the Clinical Global Impression of Change values did not significantly differ in Groups 1 and 2; however, during the course of dapoxetine administration, they were significantly more improved in Group 2 than in Group 1. The side effects were negligible and did not significantly differ between the groups. Conclusions: Dapoxetine efficacy for the treatment of lifelong PE might be improved by the wording used in the instructions.
To explore whether medical instructions might improve dapoxetine efficacy for lifelong premature ejaculation (PE). All PE patients received dapoxetine 60 mg. Sixty patients (Group 1) were given the following instructions “Take one tablet two hours before sexual intercourse; dapoxetine will delay your ejaculation” and 64 patients (Group 2) were given the following instructions “Take one tablet two hours before sexual intercourse; do not try to delay or to hold back ejaculation because dapoxetine is doing it for you. Dapoxetine will delay/improve your ejaculation within 3 months from the first assumption”. Before, and during the course of dapoxetine assumption, the stopwatch-measured intravaginal ejaculatory latency time, the Clinical Global Impression of Change and the side effects were measured in both groups. Results: The baseline intravaginal ejaculatory latency time and the Clinical Global Impression of Change values did not significantly differ in Groups 1 and 2; however, during the course of dapoxetine administration, they were significantly more improved in Group 2 than in Group 1. The side effects were negligible and did not significantly differ between the groups. Conclusions: Dapoxetine efficacy for the treatment of lifelong PE might be improved by the wording used in the instructions.