Background: Infertility is the major problem in the world and it occur due to many reasons one of in certain conditions is treatment of cancer. Justification: There is no published data concerning the association between cancer and infertility. Objectives: To know the prevalence of cancer among selected group of Sudanese ladies with fertility disorders. Method: Descriptive, cross sectional study, from March –May, 2016, at Banoon IVF center, Khartoum, Sudan, 100 Sudanese women with fertility disorders were involved in the study. Result: The prevalence of cancer among the selected group was 10% (6% was breast cancer, 4% other types of cancer). Discussion: The prevalence of cancer among the study group was high and that may give us a link between cancer and infertility with strength of this link was increased among the participants with breast cancer , then our study agree with the previous study done by Kutluk Oktay et al that showed association between breast cancer and infertility. Conclusion: Further studies should be done involving large sample size from different races.