This paper examines the relationship between the creative economy and the Pantanal territory, aiming to discuss elements that may shed light on the concept of a creative biome—that is, a creative economy inspired by the territory and its specific characteristics. The research is qualitative and adopts an interpretivist approach, with a methodological path that includes a predominantly bibliographic review. The study anticipates that a creative biome—the Southern Pantanal as a creative territory—encompasses practices, symbols, and intangible resources which, due to their uniqueness and rarity, highlight the strategic richness that can emerge from this developing space-concept.