global-journal-of-medical-research-k-interdisciplinary Global Journal of Medical Research - K: Interdisciplinary 0975-5888 2249-4618 Global Journals Publishing Group Incorporated 10.34257/GJMR145517 145517 The Enigma of Lipofibromatous Hamartoma: A Deep Dive into a Rare Pathology Lipofibromatous Hamartoma of the Median Nerve IyerDr. Sriranjani SeguDr. Smitha JKDr. Yogesh JCDr. Yogaisvariya IyerDr. Nagashri INDIA 27 12 2025 25 K4 13 25

lipofibromatous hamartoma (LFH) is a rare condition characterized by the infiltration of peripheral nerves by fibrous and adipose tissues. Patients typically present with gradually enlarging, non-tender lesions in the distribution of the affected nerve, most commonly the median nerve, which is involved in 66% to 80% of cases. Symptoms often include pain, sensory deficits, and motor dysfunction, with affected individuals reporting numbness and tingling along the volar aspect of the wrist and hand. Motor deficits tend to appear later in the course of the condition .

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lipofibromatous hamartoma (LFH) is a rare condition characterized by the infiltration of peripheral nerves by fibrous and adipose tissues. Patients typically present with gradually enlarging, non-tender lesions in the distribution of the affected nerve, most commonly the median nerve, which is involved in 66% to 80% of cases. Symptoms often include pain, sensory deficits, and motor dysfunction, with affected individuals reporting numbness and tingling along the volar aspect of the wrist and hand. Motor deficits tend to appear later in the course of the condition [1].