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<journal-id journal-id-type="publisher">global-journal-of-medical-research-a-neurology-nervous-system</journal-id>
<journal-title-group>
<journal-title>Global Journal of Medical Research - A: Neurology &amp; Nervous System</journal-title>
</journal-title-group>
<issn publication-format="print">0975-5888</issn>
<issn publication-format="electronic">2249-4618</issn>
<publisher><publisher-name>Global Journals Publishing Group Incorporated</publisher-name></publisher>
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<article-id pub-id-type="doi">10.34257/GJMRA187150</article-id>
<article-id pub-id-type="publisher-id">187150</article-id>
<title-group>
<article-title>Peptides and Lysine as Emerging Therapies for Alzheimer’s Disease: A Systematic Review</article-title>
<subtitle>Peptides and Lysine: New Alzheimer&#039;s Therapies</subtitle>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>Nava</surname><given-names>Carolina Fátima Gioia</given-names></name><xref ref-type="aff" rid="aff1" />
</contrib>
<contrib contrib-type="author"><name><surname>Merhi</surname><given-names>Aline Rodrigues Silva</given-names></name><xref ref-type="aff" rid="aff2" />
</contrib>
<contrib contrib-type="author"><name><surname>Lemes</surname><given-names>Digilany Aparecida de Souza</given-names></name><xref ref-type="aff" rid="aff3" />
</contrib>
<contrib contrib-type="author"><name><surname>Gonçalves</surname><given-names>Fernanda Laignier</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Oliveira</surname><given-names>Isabella Régia de</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Morais</surname><given-names>Nathália Gomes de</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Barros</surname><given-names>Osni Vieira de</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Sousa</surname><given-names>Dr. Elias Rafael de</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Shadman</surname><given-names>Dr. Muhammad</given-names></name></contrib>
</contrib-group>
<aff id="aff1">BRAZIL, Medical School, Institute of Health Sciences, Alfredo Nasser University Centre – UNIFAN</aff>
<aff id="aff2">Brazil</aff>
<aff id="aff3">Iran</aff>
<volume>26</volume>
<issue>1</issue>
<fpage>5</fpage>
<lpage>16</lpage>
<abstract><p>Particularly among the elderly, Alzheimer&#039;s Disease (AD) is a common neurodegenerative disease impacting millions of people. The accumulation of beta-amyloid and tau proteins defines it; this causes the gradual decline of cognitive abilities. This work examines how peptides and the amino acid lysine might help modulate AD pathological processes. By focusing on experimental and observational studies on the effectiveness of these chemicals, the approach comprised a methodical review of papers published between 2010 and 2024. The findings show that specific peptides can destabilize amyloid plaques; lysine helps neuroprotection and lessens neuroinflammation. Though the results are encouraging, strong clinical trials must confirm human efficacy and safety. The conversation underlines the need to know the underlying molecular mechanisms and the need for new therapeutic interventions. Though peptides and lysine show great promise, ongoing studies are vital to create successful plans for treating AD to enhance patient quality of life.</p></abstract>
<kwd-group kwd-group-type="author-generated">
<kwd>Therapeutic peptides</kwd>
<kwd>Alzheimer’s disease</kwd>
<kwd>Lysine</kwd>
<kwd>Molecular neuroprotection</kwd>
<kwd>Biomolecular interventions.</kwd>
</kwd-group>
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<title>Full Text</title>
<p>Particularly among the elderly, Alzheimer&#039;s Disease (AD) is a common neurodegenerative disease impacting millions of people. The accumulation of beta-amyloid and tau proteins defines it; this causes the gradual decline of cognitive abilities. This work examines how peptides and the amino acid lysine might help modulate AD pathological processes. By focusing on experimental and observational studies on the effectiveness of these chemicals, the approach comprised a methodical review of papers published between 2010 and 2024. The findings show that specific peptides can destabilize amyloid plaques; lysine helps neuroprotection and lessens neuroinflammation. Though the results are encouraging, strong clinical trials must confirm human efficacy and safety. The conversation underlines the need to know the underlying molecular mechanisms and the need for new therapeutic interventions. Though peptides and lysine show great promise, ongoing studies are vital to create successful plans for treating AD to enhance patient quality of life.</p>
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