This study analysed the impacts of the COVID-19 pandemic on the stock markets of Brazil, Mexico and Chile, using an approach that combined descriptive and time series analyses. In the descriptive analysis, different behaviours were observed in relation to the number of listed companies. In the time series analysis, the model with internal COVID-19 cases and fatalities did not have significant explanatory power, but when considering global data, Brazil and Mexico showed greater influence, while Chile was not as affected. The study suggests that the stock markets of Latin American countries have reacted differently to the pandemic, although all the stock exchanges that were the subject of this study showed a depreciation in the average capitalisation value after 2020.