Megaprojects in the Middle East—spanning public transport, e-commerce, healthcare, and large gatherings—shape economies and public services at scale. Research from leading organizations confirms that cost overruns and delays are the norm, not the exception, in large-scale projects [1, 2]. This paper positions supply chain management (SCM) as a decisive lever for predictable delivery. It synthesizes principles for early and thorough planning, transparent partnerships, adaptive logistics, and data-driven control, and illustrates them through regional examples: Dubai’s vaccine distribution hub, Noon.com’s fulfillment network in Saudi Arabia and the UAE, Dubai Metro’s staged expansion, and Hajj operations logistics. The discussion concludes with a practical leadership playbook for resilient execution.