Oil pulling is a traditional oral hygiene practice that involves the swishing of oil in the mouth to improve oral and systemic health. This in-vivo study aimed to comparatively evaluate the antibacterial and antiplaque efficacy of virgin coconut oil (VCO) combined with either peppermint oil or rosemary oil, plain VCO, and a conventional chlorhexidine mouthwash in Indian children aged 10–13 years. A total of 80 participants were randomly divided into four groups: VCO with rosemary essential oil, VCO with peppermint essential oil, plain VCO, and chlorhexidine mouthwash. The antibacterial efficacy was assessed by measuring Streptococcus mutans colony-forming units (CFU), while plaque scores and salivary pH changes were also evaluated before and after intervention. The results demonstrated a significant reduction in CFU counts and plaque scores in all groups, with the essential oil combinations showing enhanced efficacy compared to plain VCO and results comparable to chlorhexidine. Additionally, improvements in salivary pH were observed, indicating a favorable shift in the oral environment. The findings suggest that VCO combined with rosemary or peppermint oil can serve as a natural, effective alternative to conventional mouthwashes in pediatric populations.