The theory that life on planet Earth is based on the fact that plant seeds and prokaryotes have shown the ability to survive extreme environmental conditions. The objective of this research was to analyze the survival of plant seeds and genera of probiotic bacteria released in a picosatellite to the atmosphere. In that sense seeds of Beta vulgaris (beet), Lactuca sativa (lettuce), Solaneum lycopersicum, as well as probiotics Lactobacillus plantarum, Leuconostoc lactis, Bifidiobacterium citreum, were prepared in petri dishes and placed in a container of a picosatellite sent from the city of Morelia, Michoacan, Mexico: the seeds were germinated and the probiotic bacteria were evaluated before and after of the trip by the picosatellite, the experimental data were analyzed by ANNOVA-Tukey. The results indicated that only survival the seeds of B. vulgaris as well as the genera of La. plantarum and Le. lactis. This shows that in seeds and bacteria there are mechanisms that prevent the death of both in extreme conditions of the stratosphere.