This paper examined the impact of credit risk on the performance of banks in Ghana using unbalanced panel data of 16 banks over the period 1990 to 2018. OLS method of timation was adopted on a multiple regression equation. The study employed a causal design. The results indicate a significant positive relationship between net interest income and return on assets. Even though there is a negative relationship between return on assets and loan loss provision on one hand and Interest Rate Spread on the other they are insignificant.