The objective of this study is to assess the relationship between employee empowerment and motivation on job satisfaction in the Ghana Education Service (GES), using Atwima Mponua District in the Ashanti Region as a case. The study adopted primary data which was solicited from two hundred teachers who were conveniently sampled from the Atwima Mponua District of the GES with a structured questionnaire on a five-point Likert Scale. Data collected were analysed quantitatively using both descriptive and inferential statistics with SPSS version 21. The study found a positive effect between employee empowerment on motivation at 5% level of significance. The study also found a positive effect of employee motivation and empowerment on job satisfaction in the GES. Given that salaries, incentives, job security, and working conditions are the most important determinants of teachers’ satisfaction and increased performance, the study recommends that the government collaborate with GES to make these issues policy priorities.