The study reflects the impact of an effective multilateral exchange rate in the 1989-2018 period on the economic growth rate of 5 ASEAN countries, including Vietnam, Indonesia, Singapore, Philippines, and Malaysia. To estimate this model, the author uses the Fixed Effects and Random Effects panel data estimation method. Hausman test shows the model calculated using the Fixed Effects method is more suitable than the Random Effects method. In the estimation model, however, heteroskedasticity and autocorrelation came using the Fixed Effects method. Using Prais-Winsten (PCSE) process, the authors overcame the phenomenon. The final model shows that an improvement of 1% in the effective exchange rate would have a positive impact, growing the five countries’ economic growth rate by 16.2%.