Due to their unique properties, nanoparticles made of polysaccharides are promising carriers to deliver and protect the physiological properties of hydrophilic drugs. They have been successfully applied as drug delivery systems (83). Objective: The main goal of this research is to Improve Carbamazepine water solubility and drug release properties by nano sizing, and using guar gum, Acacia Gum and poly-vinylpyrrolidone, each of two viscosity grades, as crosslinking agents. Moreover, the study is extrapolated, utilizing composite index (CI) design and mathematical modelling, in an attempt to locate the most suitable set of the factors that affect nanoparticles produced with optimum specifications.