Background: Weight changes during chemotherapy in women with cancer breast cancer are commonly suggested by the medical literature. The association between gain weight and chemotherapy has shown a general trend of decreasing magnitude in last years. The consequence on disease-free survival and self-esteem in patients with breast cancer after chemotherapy highlights the importance of research on the topic. This study aims to evaluate weight changes in patients with non-metastatic breast cancer undergoing adjuvant and/or neoadjuvant chemotherapy in a oncology in southern Brazil. Methods: Data from 122 medical records center of high complexity oncology in Southern Brazil for patients diagnosed with non- metastatic malignant breast cancer and undergoing chemotherapy for one year. Statistical analysis was performed by SPSS v.20.0.