Introduction: IgA nephropathy, an indirect immune-mediated kidney disease, is considered the main etiology of glomerulopathies and is also responsible for a large partofall cases of end-stage chronic kidney disease. Objective: To report the case of a patient admitted to a hospital with clinical presentation of mixed syndrome and presence of vasculitis in the lowerlimbs, with a diagnostic hypothesis of IgA nephropathy. Methodology: The information was obtained by reviewing the chart, photographing the diagnostic methods to which the patient was submitted and reviewing the literature. Discussion: Studies point to the pathogenic mechanism from the deposition of circulating immune complexes in the renal glomerulus, leading to inflammation and activation of the immune system. The clinical presentationis variable, with the mixed syndrome being the most frequent.