Background: Cardiac lymphoma is one of the rarest tumors involving the heart that have polymorphous and non-specific clinical symptomatology (1); it’s preferential location is rather the right-sided cardiac chambers. Echocardiography and MRI are the diagnosis methods of choice for this location. The tumor is rapidly fatal unless diagnosed and treated in time. Case Presentation: A 65 year old woman was referred for worsening exertional dyspnea , primary examination revealed a stable patient, Unilateral edema was noted with decreased sloshing of the left calf. The electrocardiogram showed a sinus tachycardia and the transthoracic echo revealed the presence of multiple intra cardiac masses (RA, RV, LV), with pericardial thickening and minimal pericardial effusion. Cardiac MRI showed a pericardial thickening extending to the basal vessels associated with several masses at the expense of the lateral wall of the RA, RV, LV. An attempted echo-guided biopsy of the mediastinal lymphadenopathy was performed but the patient did not support the procedure.