Introduction: Sudden cardiovascular death (SCD) constitutes the main challenge for Cardiology in this century. One out of every two cardiovascular deaths is due to this universal health problem. Objective: To present scientific evidence that justifies this global challenge, and to mention the research results of the Research Group on Sudden Death (GIMUS) of Cuba. Material and method: Research results of the SUCADES study carried out in Cuba (1995-2020) are presented, applying the research protocol contained in the Cuban Guide for SCD research works. Results: The GIMUS has developed in a period of 25 years’ scientific research with the application of a diagnostic algorithm and the use of a Primary Data Collection Model to 33 718 natural deaths, documenting 2 252 sudden deaths, representing 6.6% of global mortality recorded.