Introduction: SARS (severe acute respiratory syndrome) is the severe stage of COVID- 19 caused by massive alveolar damage and progressive respiratory failure; caused by SARSCoV- 2 (SARS coronavirus 2). Objective: To show the beha vior of the incidence of COVID-19 and vaccination against SARSCOV- 2, between the period between February 17 and September 30, 2021. Methodology: This research was carried out under a cross-sectional study, as a source of information, it was obtained from the national vaccination plan against COVID-19 from the website of the Ministry of Health and Social Protection. Results: An increase in incidence was evidenced over time, the number of vaccines also increased, until June 2021. From July 2021 to September 2021, there was a decrease in the incidence of SARS- CoV-2, as well as the decrease in the application of the number of vaccines. Conclusion: There is a demand for more studies predestined to evaluate the efficacy of vaccination in reducing the transmission of SARS-CoV-2 in Colombia, both at the individual level and at the population level, with a greater longitudinal tracing and in additional populations.