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<journal-meta>
<journal-id journal-id-type="publisher">global-journal-of-medical-research-b-pharma-drug-discovery-toxicology-medicine</journal-id>
<journal-title-group>
<journal-title>Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology &amp; Medicine</journal-title>
</journal-title-group>
<issn publication-format="print">0975-5888</issn>
<issn publication-format="electronic">2249-4618</issn>
<publisher><publisher-name>Global Journals Publishing Group Incorporated</publisher-name></publisher>
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<article-meta>
<article-id pub-id-type="publisher-id">59996</article-id>
<title-group>
<article-title>From the Histological Model to the Mutational Model: The Study of Heavy Metals and Other Substances in New Antineoplastic Therapies</article-title>
<subtitle>Impact of Pollution and Nutrition on Cancer Therapy</subtitle>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>Ruffolo</surname><given-names>Pasquale</given-names></name><xref ref-type="aff" rid="aff1" />
</contrib>
<contrib contrib-type="author"><name><surname>Acquaviva</surname><given-names>Osvaldo</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Capece</surname><given-names>Pierpaolo</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Ruffolo</surname><given-names>Bruno</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Panunzio</surname><given-names>Manuela</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Paraggio</surname><given-names>Alessandra</given-names></name></contrib>
</contrib-group>
<aff id="aff1">ITALY</aff>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2023-07-06">
<day>06</day>
<month>07</month>
<year>2023</year>
</pub-date>
<volume>23</volume>
<issue>B1</issue>
<fpage>7</fpage>
<lpage>9</lpage>
<abstract><p>The study of genetic mutations in tumours changes the therapeutic approach; in fact, we move into a different advanced and strategic phase by entering personalized precision medicine and shifting the focus from the tissue study of the tumour to the modification and proliferation of neoplastic cells. The therapeutic programs, especially in oncology, are changing. We are in a phase of transition from the histological model to the model of genetic mutation (mutation). When a person’s immune defences do not respond to a disease it is because the body cannot produce or activate specific lymphocytes and antibodies against that disease. This causes of a lack of therapeutic response or recurrence of the disease.</p></abstract>
<kwd-group kwd-group-type="author-generated">
<kwd>tumour disease</kwd>
<kwd>therapeutic response</kwd>
<kwd>complications</kwd>
<kwd>genomic modification</kwd>
<kwd>genomic and genetic tests.</kwd>
</kwd-group>
<self-uri content-type="pdf" xlink:href="https://globaljournals.org/GJMR_Volume23/2-From-the-Histological-Model.pdf" />
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</article-meta>
</front>
<body>
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<title>Full Text</title>
<p>The study of genetic mutations in tumours changes the therapeutic approach; in fact, we move into a different advanced and strategic phase by entering personalized precision medicine and shifting the focus from the tissue study of the tumour to the modification and proliferation of neoplastic cells. The therapeutic programs, especially in oncology, are changing. We are in a phase of transition from the histological model to the model of genetic mutation (mutation). When a person&#039;s immune defences do not respond to a disease it is because the body cannot produce or activate specific lymphocytes and antibodies against that disease. This causes of a lack of therapeutic response or recurrence of the disease.</p>
</sec>
</body>
</article>