Waldenstrom’s Macroglobulinemia (MW) is characterized by a type of mature B-cell non-Hodking lymphoma with proliferation of lymphoplasmocyte elements in the bone marrow and presence of monoclonal immunoglobulin M gamopathy. Given the rarity of the disease, the wide spectrum of hematopathies can mask the diagnosis of this disease. Therefore, the identification of immunophenotypes is one of the main medical challenges for making an early diagnosis. The present study brings a retrospective and descriptive essay, based on systematic reviews around the main biological markers used to make the diagnosis of patients with Waldenstrom’s Macroglobulinemia, through the active search for original articles in the Pubmed, Science direct, Scielo, UpToDate and Portal Capes databases. Six articles with a specific theme were selected, categorized according to the differential diagnoses of Waldenstrom’s Macroglobulinemia.
Waldenstrom's Macroglobulinemia (MW) is characterized by a type of mature B-cell non-Hodking lymphoma with proliferation of lymphoplasmocyte elements in the bone marrow and presence of monoclonal immunoglobulin M gamopathy. Given the rarity of the disease, the wide spectrum of hematopathies can mask the diagnosis of this disease. Therefore, the identification of immunophenotypes is one of the main medical challenges for making an early diagnosis. The present study brings a retrospective and descriptive essay, based on systematic reviews around the main biological markers used to make the diagnosis of patients with Waldenstrom's Macroglobulinemia, through the active search for original articles in the Pubmed, Science direct, Scielo, UpToDate and Portal Capes databases. Six articles with a specific theme were selected, categorized according to the differential diagnoses of Waldenstrom's Macroglobulinemia.