Background: The study of the association between acne vulgaris and the TNF- gene polymorphism rs1800629 in the Uzbek population is discussed in this article. Methodology: The research was conducted on 165 patients with various clinical forms of acne vulgaris and 161 healthy donors. Findings: During this research, allele frequencies and genotypes of rs1800629 polymorphism of TNF-α gene were found with statistically significant differences between the control group and subgroups of patients with acne vulgaris. As a result of the investigation, it was discovered that heterozygous genotype G/A should be a genetic marker for an increased risk of acne development, whereas homozygous genotype G/G should be a marker for a reduced risk of acne formation.