The object of the study is a liquid alcoholic extract under the code name "Parodonfit" - containing medicinal plants, such as Salvia officinalis, Matricariachamomilla, Calendula officinalis, Hypericumper for atum. The chemical composition of this phytocomposition was previously studied. Moreover, alkaloids, flavonoids, saponins and tannins were found in the composition of the liquid extract. Given the traditional use of this phytocomposition in dentistry, it is of undoubted interest to develop a dental dosage form based on it for the treatment of diseases of the oral mucosa. The article presents the results of a study of acute toxicity of the Parodonfit liquid extract.