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<journal-meta>
<journal-id journal-id-type="publisher">global-journal-of-medical-research-b-pharma-drug-discovery-toxicology-medicine</journal-id>
<journal-title-group>
<journal-title>Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology &amp; Medicine</journal-title>
</journal-title-group>
<issn publication-format="print">0975-5888</issn>
<issn publication-format="electronic">2249-4618</issn>
<publisher><publisher-name>Global Journals Publishing Group Incorporated</publisher-name></publisher>
<self-uri xlink:href="https://globaljournals.org/journal-seo-export/jats/60401.xml" />
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<article-meta>
<article-id pub-id-type="publisher-id">60401</article-id>
<title-group>
<article-title>Efficacy and Safety of Vitamin D3 (Cholecalciferol) Oral Solution Compared to Tablet and Capsule: A Randomized, Parallel-Design, Active-Controlled Study</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>Nandgaye</surname><given-names>Krishnakumar M</given-names></name><xref ref-type="aff" rid="aff1" />
</contrib>
<contrib contrib-type="author"><name><surname>Kadam</surname><given-names>Santoshi B.</given-names></name></contrib>
<contrib contrib-type="author"><name><surname>Palkar</surname><given-names>Dr. Prashant J.</given-names></name></contrib>
</contrib-group>
<aff id="aff1">INDIA</aff>
<pub-date publication-format="electronic" date-type="pub" iso-8601-date="2020-01-15">
<day>15</day>
<month>01</month>
<year>2020</year>
</pub-date>
<volume>20</volume>
<issue>B5</issue>
<fpage>1</fpage>
<lpage>6</lpage>
<abstract><p>We performed a study to compare the efficacy of Vitamin D 3 oral solution with a conventional tablets and capsules in hypovitaminosis D patients. One hundred eighty subjects were divided into three different groups and received vitamin D 3 60000 IU per week for eight weeks either in the form of an oral solution or a tablet or a capsule. A significant increase in serum 25(OH)D was observed in vitamin D 3 oral solution from baseline (P=0.0001) as compared to a tablet (P=0.0001) and capsule (P=0.0001). A significant decrease in iPTH levels was seen in the vitamin D 3 oral solution group from baseline (P=0.0001) and also as compared to a tablet (P=0.0001) and capsule (P=0.0001). Oral solution of vitamin D 3 is a nanotechnology-based formulation which was found to be effective and safe. Thus, treatment with vitamin D 3 oral solution in hypovitaminosis D patients may result in faster and higher improvement in the normalization of vitamin D levels.</p></abstract>
<kwd-group kwd-group-type="author-generated">
<kwd>nanotechnology</kwd>
<kwd>hypovitaminosis D</kwd>
<kwd>vitamin D3 oral solution</kwd>
<kwd>vitamin D3 60000 IU.</kwd>
</kwd-group>
<self-uri content-type="pdf" xlink:href="https://globaljournals.org/GJMR_Volume20/1-Efficacy-and-Safety-of-Vitamin-D3.pdf" />
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<p>We performed a study to compare the efficacy of Vitamin D3 oral solution with a conventional tablets and capsules in hypovitaminosis D patients. One hundred eighty subjects were divided into three different groups and received vitamin D3 60000 IU per week for eight weeks either in the form of an oral solution or a tablet or a capsule. A significant increase in serum 25(OH)D was observed in vitamin D3 oral solution from baseline (P=0.0001) as compared to a tablet (P=0.0001) and capsule (P=0.0001). A significant decrease in iPTH levels was seen in the vitamin D3 oral solution group from baseline (P=0.0001) and also as compared to a tablet (P=0.0001) and capsule (P=0.0001). Oral solution of vitamin D3 is a nanotechnology-based formulation which was found to be effective and safe. Thus, treatment with vitamin D3 oral solution in hypovitaminosis D patients may result in faster and higher improvement in the normalization of vitamin D levels.</p>
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