Increased life expectancy, lengthening of the reproductive period, early menarche and late menopause, chronic hyperestrogenism in the presence of relative or absolute progesterone deficiency, uncontrolled use of combined oral contraceptives, the formation of the metabolic syndrome are considered high-risk factors for the occurrence and progression of this pathology. Therefore, we aimed to study improvement the principles of preventing the loss and restoration of bone mineral density in women in the perimenopausal period. In women with unfavorable factors of menstrual, reproductive, somatic history in the perimenopausal period, there is a high incidence of the development of pathological decrease in bone mineral density. The use of combined oral contraceptives in the perimenopausal period contributes to the activation of bone remodeling processes.