The mortality due to tuberculosis is high among the human immunodeficiency virus (HIV)-infected children. A confirmative diagnosis of tuberculosis is difficult to obtain, especially in a resource-limited setting. A clinician might, therefore, go for the diagnostic criteria with higher sensitivity to avoid under-diagnosis and delayed treatment. The diagnosis of probable tuberculosis by Osborne’s method is a good option in such a situation. The present study includes 42 HIV-infected subjects diagnosed with probable tuberculosis using Osborne’s method. During a treatment period of 6-9 months; 39(91%) “felt better”, 28(67%) gained weight and 2 (4.7%) died.