Background: Cadaba farinosa fork is widely used traditionally as mucosae plant medicine for treatments of diarrheal, dysentery, intestinal parasites, and ulcerative peptic diseases that are hard to cure even with conventional medicines. Aim and Objective: The main aim of the study is to evaluate the possible histological effects of aqueous stem bark extract of Cadaba farinosa on the gastrointestinal tract of Wistar rats. Materials and Methods: The lethal dose (LD50) of aqueous stem bark extract of Cadaba farinosa was determined using the Lorke’s method. Thirty (30) male and female Wistar rats were selected and randomized into five groups of six rats per group. Group 1 served as the control group, and no extract was administered to the experimental animals while the rats in groups 2, 3, 4, and 5 were administered by gavage dose levels 100, 200, 300, and 400 mg/kg extract for twenty-eight days.