Introduction: Screening for Transfusion transmitted infections (TTI’s) is done to provide safe blood. Very often donors are found to be seropositive for one or more of the TTI’s. The present study was undertaken in a blood bank of a tertiary care hospital to determine the response rate of the blood donors after they were notified about their reactive status. Materials and Methods: The one year observational study was done in a prospective manner from January 2013 – December 2013 taking in account of all the registered donors coming to the blood bank after notification.