Ovariohysterectomy was performed via ventral midline clinical cases in dogs (n=35) to present haematobiochemical changes and postoperative complications of elective ovariohysterectomy under dexmedetomidine basal anaesthesia in dogs. Total Leukocyte count and Haemoglobin concentration decreased, whereas, glucose increased significantly. There was a no significant change in neutrophil count, packed cell volume, creatinine, insulin and cortisol. Complications were observed in seven out of thirty five animals. Intra-abdominal haemorrhage was observed in three, abdominal wound dehiscence in 3 animals and ovarian remnant syndrome occurred in one dog. Stress response to surgeries was obtunded dexmedetomidine induced basal anaesthesia.