A CT scan is a tool that has been demonstrated to be optimal for response evaluation in gastrointestinal stroma tumors that undergo targeted therapy. In this study, response and evaluation of gastrointestinal stroma tumors were compared with the use of targeted therapy according to CHOI criteria in Oncology Siglo XXI Hospital patients. Materials and Methods: A retrospective study from January 2009 to January 2014 in patients with a confirmed diagnosis with access to CT scan; a response to the treatment was observed according to CHOI criteria. Results: A total of 31 patients were enrolled in this study, 61% received targeted therapy with Imatinib and 38% received second-line Imatinib and Sunitinib treatment, with a minimum follow up of 6 months and a maximum of one year. According to CHOI criteria, 45.2% of the patients reached CR, 19.4% had SD, 19.4% reached PR, and 16.1% had PD.