Introduction: Injection is an infusion method of putting drugs or fluids in to the body with a hollow needle and a syringe. The use of injection for treatment accompanied with variety of disadvantages including sepsis at administration, risk of tissue toxicity, costly difficulties in correcting the error. Injections are very expensive compared to other dosage forms and require trained personnel for administration. Moreover, unhygienic use of injections can increase the risk of transmission of potentially serious pathogens, such as hepatitis, HIV/AIDS, and blood-borne diseases. It is estimated by the WHO that about 16 billion injections are undertaken in developing countries annually and are often irrationally used. Objective: The present study was aimed to assess the prescription pattern of injections in Adama Hospital Medical College. Method: Hospital based Prospective cross sectional study was done to assess prescription pattern of injections in outpatient pharmacy of AHMC. All Prescription cards from March 24, 2015 to May 24, 2015 were taken and reviewed using pretested data collection format. Finally data was edited, coded, tallied and cleaned. Descriptive statistics was computed.