Under the basic premise that an economy and its territory as a socioeconomic entity, are inscribed into a nation’s space. Accordingly, the concomitant sustainable handling of its natural resources and people´s well-being depends on myriad factors among which stands out firstly, the country's own socioeconomic dynamics and secondly, but not least important, the political capacity of the State´s intervention into the economy, as the foremost legal entity capable and social risponsible to advance the nation´s economic strategy, to promote simultaneously growth and social well-being into the nation. Upon this framework, the article aims at analyze the socioeconomic implications of the neoliberal economic strategy adopted by Mexico, with particular reference to Mexico City (CDMX) vis-à-vis Mexico’s Center Region (encompassing CDMX and neighboring states) to demonstrate its failure and the compelling need to it towards a more balanced, social-inclusive and sustainable one. Time´s horizon for the analysis ranges from 1980-2020e.