Rural non-farm activities are adaptation strategies that local communities develop as socioeconomic alternatives, for facing imposed restrictions in protected areas. To highlight these strategies, this study aimed to relate the socioeconomic variables of social agents (SAs) with their perceptions about the impact of rural non-farm enterprises (RNFEns) on the Buen Vivir of their community as residents of the Sustainable Development Reserve of Tupé, Manaus, Amazonas. In this exploratory research, through semi-structured interviews and participatory observations, the perceptions of the SAs about the dimensions of Buen Vivir (Psychological Well-Being, Time Use, Community Vitality, Culture, Environment, and others) were evaluated and how these perceptions relate to the socioeconomic variables of the RNFEns. In the perception of the SAs, the RNFEns positively impact Buen Vivir in the dimensions with the strongest collective tendency and negatively in the dimensions with the strongest private tendency, with pluriactivity being the explanatory variable.