Background: Video gaming has become an increasingly popular and globally recognized phenomenon in recent years. While playing, there are multi repetitive movements of the fingers, which may lead to significant hand grip or pinch grip problems. Purposes: The purpose of this study was to investigate the effect of prolonged use of video games on the grip and pinch strength. Materials and Methods: Forty male students from King Abdulaziz University participated in this study, their age ranged from 18-24 years. They were divided into two groups, prolonged user, and non- user group. The hand grip and pinch strength for all participants were measured by a handheld dynamometer and the level of video game addiction was assessed by Game Addiction Test. Results: There was a significant decrease in hand grip strength of the prolonged user group compared with non-user group, while there was a non-significant difference between both groups in the pinch strength. The result showed a nonsignificant correlation between hours of playing and Video game addiction Teat (VAT) with hand grip strength and pinch strength. Conclusion : There was a significant decrease in hand grip strength of the prolonged users of video games, while there was a non-significant decrease in the pinch strength in the prolonged user group compared with non- user group.