global-journal-of-human-social-science-h-interdisciplinary Global Journal of Human-Social Science - H: Interdisciplinary 0975-587X 2249-460X Global Journals Publishing Group Incorporated 62376 Hepatoprotective Effect of Merlot Grape Pomace Extract Against Acetaminophen Induced Damage in Mouse Hepatoprotective Effects of Merlot Grape Pomace LocatelliClaudriana SpaderViviane Cassaneli CarvalhoDiego de GambaConrado de Oliveira VeigaNatan LuzKarine BRAZIL 27 01 2024 23 H9 1 10

This study investigated the benefits of Merlot grape pomace extract (EBUM) in experimental acetaminophen-induced intoxication. Swiss mice received the respective treatments for 7 days: Control (saline), Silymarin (100 mg/Kg), EBUM: 100 mg/Kg and 500 mg/Kg. On the seventh day, the acetaminophen control, Silymarin and EBUM received a single dose of acetaminophen 500 mg/kg. After 24 hours, the mice were sacrificed, the blood and liver were collected for analysis of serum transaminases (ALT and AST), bilirubin, hepatic markers of oxidative stress and histopathological analysis. EBUM was able to prevent acetaminopheninduced hepatic necrosis with a significant reduction (p

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This study investigated the benefits of Merlot grape pomace extract (EBUM) in experimental acetaminophen-induced intoxication. Swiss mice received the respective treatments for 7 days: Control (saline), Silymarin (100 mg/Kg), EBUM: 100 mg/Kg and 500 mg/Kg. On the seventh day, the acetaminophen control, Silymarin and EBUM received a single dose of acetaminophen 500 mg/kg. After 24 hours, the mice were sacrificed, the blood and liver were collected for analysis of serum transaminases (ALT and AST), bilirubin, hepatic markers of oxidative stress and histopathological analysis. EBUM was able to prevent acetaminophen-induced hepatic necrosis with a significant reduction (p