The paper examines the impact of fiscal policy on certain macroeconomic variables in Nigeria from 1980 to 2015. We used Government Expenditure, Total tax revenue, Unemployment rate and Gross Domestic Product (GDP) variables data from CBN statistical bulletins. Our econometric analysis used was the Ordinary Least Square (OLS) and co-integration. The OLS result revealed that there is a significant relationship between government expenditure and unemployment rate, as well as economic growth in Nigeria, but there was no substantial relationship between government tax revenue and unemployment in Nigeria, as well as no serious relationship existed between the government tax revenue and economic growth in Nigeria. The results of the co-integration text revealed a long-run relationship among the variables; and the study suggests that government should implement appropriate fiscal policies to stimulate the economy and also find answers to reduce the unemployment rate, use necessary financial policy tools to fine-tune the economy in terms of government spending and taxation to enhance the economic growth of Nigeria.