global-journal-of-research-in-engineering-j-general-engineering Global Journal of Research in Engineering - J: General Engineering 0975-5861 2249-4596 Global Journals Publishing Group Incorporated 73355 Formulation and Control of Biodegradable Injectable In Situ Gelling System of Levonorgestrel khezrimostafa IRAN, Islamic Azad University, Tehran, Iran 22 06 2011 11 J7 15 20

The aim of this study was to develop a new polymeric gel that used as a contraceptive system.Polymeric gel has been studied extensively for drug delivery systems. In this article, thermalsensitive poly (DL-lactic acid)-poly (ethylene glycol) -poly (DL-lactic acid) (PLA-PEG-PLA) hydrogel was used as an implantable contraceptive system.Aqueous solution of this copolymer fromed a free flowing so at room temperature and became a gel at body temperature. In this study, the biodegradable copolymer with molecular structure of PLA-PEG-PLA was synthesized and was investigated the sol-gel transition, hydrolytic degradation and In-vitro drug delivery from the system. In the current studyLevonorgestrel was selected as a model contraceptive drug.

 thermal-sensitive biodegradable in situ injectable sol-gel transition Full Text

The aim of this study was to develop a new polymeric gel that used as a contraceptive system.Polymeric gel has been studied extensively for drug delivery systems. In this article, thermal- sensitive poly (DL-lactic acid)-poly (ethylene glycol) - poly (DL-lactic acid) (PLA-PEG-PLA) hydrogel was used as an implantable contraceptive system.Aqueous solution of this copolymer fromed a free flowing so at room temperature and became a gel at body temperature. In this study, the biodegradable copolymer with molecular structure of PLA-PEG-PLA was synthesized and was investigated the sol-gel transition, hydrolytic degradation and In-vitro drug delivery from the system. In the current studyLevonorgestrel was selected as a model contraceptive drug.