global-journal-of-medical-research Global Journal of Medical Research 0975-5888 2249-4618 Global Journals Publishing Group Incorporated 73693 L-lysine Neuro-Dynamic Optimal Control IlkovaDr. Tatiana PetrovDr. Mitko BULGARIA, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences 04 12 2011 11 4 55 60

In this paper Neuro-dynamic programming (NDP) is proposed as an alternative to alleviate the “curse of dimensionality” of the Dynamic programming (DP) for optimal control of a fed-batch fermentation process in the L-lysine production. The most effective and cheapest method for the Llysine biosynthesis (in biological active form) is the microbiological method via a direct fermentation. In this paper an optimization method of the L-lysine production from strain Brevibacterium flavum 22LD is used and that is NDP. The results show that the quality of L-lysine enhances at the end of the process. The proposed method is particularly simple to implement and can be applied for on-line optimization.

 dynamic programming neural network Llysine fermentation optimal control Full Text

In this paper Neuro-dynamic programming (NDP) is proposed as an alternative to alleviate the “curse of dimensionality” of the Dynamic programming (DP) for optimal control of a fed-batch fermentation process in the L-lysine production. The most effective and cheapest method for the Llysine biosynthesis (in biological active form) is the microbiological method via a direct fermentation. In this paper an optimization method of the L-lysine production from strain Brevibacterium flavum 22LD is used and that is NDP. The results show that the quality of L-lysine enhances at the end of the process. The proposed method is particularly simple to implement and can be applied for on-line optimization.