In this paper the principal objective is to find the deflection of orthotropic box cam profile countered by segments of circular-arc due to the effect of contact loading which produce the generate force that induces high contact stress on the cam-surface especially in high-speed machine. In highspeed it can be used the composite cam, since it affects the whole machine performance to improve the wear resistance. Several researchers investigated the effects of cam profile in accuracy and system flexibility on the output motion experimentally; but there is a lake in the theoretical part. The theoretical part has been done with the solution of orthotropic circular plate equation using the harmonic deflection motion of the follower. The cam used in this paper can be seen in composite shifter cam for a motorcycle transmission, composite hollow cam-shafts, the running valve lift with roller followers of a composite camshaft, and heavy duty of marine engine. The aim of the present paper is to find the maximum deflection of orthotropic box cam on the boundaries of the three circular-arc contact profiles for flanks and noses of contact follower loadings. The results were arrangement into theoretical part and finite element using software ANSYS 12.1.