Field Studies were conducted at the Federal University of Technology, Owerri, Nigeria to determine the influence of weed interference on the growth and yield of three okra (Abelmochus Keywords : Okra varieties, South-eastern Nigeria, weed interference, weed control efficiency, fruit yield. GJSFR-D Classification : FOR Code: 070308 Growth and Yield Response of Okra Abelmoschus esculentus L. Moench Varieties to Weed Interference in South-Eastern Nigeria Strictly as per the compliance and regulations of : esculentus (L) Moench) varieties. Three varieties of okra (NHAe47-4, Lady’s finger and V35) were weeded using five weeding regimes (weedy check, unweeded till 5 weeks after sowing (WAS), weeding once each at 3 WAS and 4 WAS and weed free). The treatment combinations were laid out in a randomized complete block design with three replications. Plant height for okra varieties was in the decreasing order of Lady’s finger < NHAe47-4 < V35 while leaf area was in the increasing order of NHAe47-4>V35> lady’s finger in both years. More flowers/plant were obtained from NHAe47-4 while the least number of flowers aborted were obtained from the Lady’s finger. Among the weeded plots, NHAe47-4 produced the highest fresh fruit yield (23.63t ha-1 in 2007 and 22.96t ha-1 in 2008) which were not insignificantly different from the yields obtained from weed free plots that produced 24.20t ha-1 in 2007 and 22.13t ha-1 in 2008.