global-journal-of-science-frontier-research-b-chemistry Global Journal of Science Frontier Research - B: Chemistry 0975-5896 2249-4626 Global Journals Publishing Group Incorporated 75196 Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents M.F.MadkourHassan BalochDr. Nizam EGYPT, University of Balochistan, Quetta, Pakistan and Ain Shams University, Cairo, Egypt. 13 11 2012 12 B7 27 32

The present work aims at study of antileishmanial activity of some 6, 8-dichloro-2methyl-4H-chromen-4-one derivatives. The synthesized chromenes have been screened for antileishmanial activity on L. major parasite. The results were promising and showed that all compounds under investigation have some degree of activity against leishmania L. major parasite and compound 5 showed potential activity with IC 50 value 0.58± 0.09 μg/ml, comparatively with the standard drug Amphotericin B.

 2-methyl-4h-chromen-4-one carbon electrophiles and nucleophiles leishmaniasis. Full Text

The present work aims at study of antileishmanial activity of some 6, 8-dichloro-2-methyl-4H-chromen-4-one derivatives. The synthesized chromenes have been screened for antileishmanial activity on L. major parasite. The results were promising and showed that all compounds under investigation have some degree of activity against leishmania L. major parasite and compound 5 showed potential activity with IC50 value 0.58± 0.09 μg/ml, comparatively with the standard drug Amphotericin B.