Edo State, the 'Heartbeat of Nigeria', has been labeled as “the most endemic source of human trafficking in Nigeria”. As a result of this negative label, a number of international organizations and non-governmental organizations have intervened to combat sex trafficking in the region. Despite these interventions, sex trafficking is still rife in Edo State. This article argues that political, economic, religious, social and cultural factors contribute to the difficulties in curbing sex trafficking in Edo State. To eradicate it, a joint effort between the government, traditional leaders, religious institutions/NGOs and members of the public is needed.