The paper discussed organizational culture and employees’ performance in the National Agency for Food and Drugs Administration and Control (NAFDAC), Nigeria. It views organizational culture as shared values, beliefs and norms that influence the way employees think, feel and behave in the workplace. It assumes that a positive organizational culture will enhance employees’ performance. The research question adderssed the extent of the relationship between organizational culture and increased employees commitment/ productivity in NAFDAC. The place of study consists of the 6 zonal and 36 state offices of NAFDAC in Nigeria while the duration of study is between February 2013 and January 2014.A descriptive research design was used in executing the study using 420(judgmentally determined) randomly selected NAFDAC employees from its zonal/state offices in Nigeria for questionnaire administration. Data collected were analyzed using descriptive and inferential statistics. Results from the data analysis indicated that significant relationship exists between organizational culture and increased employees commitment/productivity in NAFDAC and recommends among others: continuous staff training, increased government funding, continuous improvement of employees’ condition of service, continuous improvement of employees’ condition of service, sustenance of the prevailing organizational culture of decentralization and current team building efforts.