Introduction: Shack fires are very common at the informal settlements around South Africa - leading to an increase in number of victims of burn injuries. Case History: A 32 year old with no known past medical history sustained 35% Total Body Surface Area (TBSA) partial thickness and full thickness burns to the chest, back, head and both arms due to a shack fire. Seven days after admission, the patient's developed infective endocarditis and acute aortic regurgitation. Despite the appropriate antibiotic treatment of Piptaz and cloxacillin administered for five days after the infection was detected, the patient died due to complications of the disease process