global-journal-of-medical-research-b-pharma-drug-discovery-toxicology-medicine Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine 0975-5888 2249-4618 Global Journals Publishing Group Incorporated 82573 A Validated Method for Simultaneous Quantification of Four Antiretrovirals in Dried Blood Spot and Plasma Using LC-MS/MS: Application to Efavirenz Therapeutic Drug Monitoring in Pregnant Patients DuarteMaira Ludna SilvaAurylanne Mikaelle Brandão SilvaJosé Wellithom Viturino da SantanaDavi Pereira CastroWhocely Victor de AlencarLuiz Cláudio Arraes de BRAZIL 22 B1

The specific physiological background induced by pregnancy leads to significant changes in maternal pharmacokinetics, suggesting potential variability in plasma concentrations of antiretrovirals. Therefore, pregnant women may be exposed to subtherapeutic doses, particularly in the later stages of pregnancy, which may increase the risk of HIV transmission from mother to child.

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The specific physiological background induced by pregnancy leads to significant changes in maternal pharmacokinetics, suggesting potential variability in plasma concentrations of antiretrovirals. Therefore, pregnant women may be exposed to subtherapeutic doses, particularly in the later stages of pregnancy, which may increase the risk of HIV transmission from mother to child.