Background: Worldwide every one minute one woman dies from pregnancy or child birth related complications. This study attempt to compare efficacy of Carboprost versus Oxytocin for active management of third stage of labour. Methodology: Three hundred obstetric cases anticipated for spontaneous vaginal delivery were randomly divided into two groups. Out of which 150 received Intramuscular oxytocin 10 units and 150 cases received Intramuscular Carboprost 125 μg after the delivery of the baby. The main outcome measured with respect to outcome of third stage of labor were: duration, blood loss by volume, difference in hemoglobin, need for additional oxytocics and side effects.