Bio
Kuat Oshakbayev is a researcher affiliated with the Republican Scientific Center for Emergency Medicine in Astana, Kazakhstan. His work focuses on emergency medicine and metabolic health, with notable contributions including a randomized controlled clinical trial on weight loss programs in patients with atherosclerosis and a study on the heating value of human body lipids from different anatomical locations. Dr. Oshakbayev's research addresses critical aspects of cardiovascular and metabolic disorders, reflecting his commitment to advancing clinical knowledge in Kazakhstan.
Experience
Republican Scientific Center for Emergency Medicine
0 - 0Research
The Heating Value of a Different Location of Human Body Lipids
Background: Distribution character of fats can influence to emergence of different severe life-threatens diseases.Body lipids morphology is enough well investigated, but there is little data on the calorific properties of various lipids, including atherosclerotic plaque (AP).Aim of the study was to investigate the calorific properties of a human body lipids of various anatomical sites. Methods : Trial design is a prospective randomized pilot physical experimental trial. Adipose tissue in the amount of 252 samples from 36 individuals (17 female sex) at autopsy. The subjects were dying from various injuries and were between 36-54 years old. Interventions: Differential scanning calorimetry («Mettler Toledo», USA) was used with an increments temperature of 10.37 °C per minute. In an experimental set up specimens were heated up from 26.0 °C to 700.0 °C for 70.0 minutes. Results: The heat capacity of the studied lipids decreases from AP (dense) to AP (loose), VF (omentum fat), SF (umbilical area), SF (shoulder area), SF (buttock area) and VF (pararenal fat). The dense AP (-3, 97±0,16oC) has higher a heat capacity (p=0.02) than the loose AP (-3, 44±0,15oC). The lowest thermal capacity has a pararenal fat of VF (-1, 25±0,21oC) in compare with SF (buttock area) (p=0.027). ConclusionsIn: Conclusion, the fats of a human body have different calorific properties depending on a location. Atherosclerotic plaques carry the highest energy potential in comparison to the other body lipids. The lowest thermal capacity has pararenal fats. The results of the study suggest that an atherosclerotic plaque is not an accidental phenomenon in the body, but it is a logical pathophysiological process in result of fats compaction.
Weight Loss Program in Patients with Atherosclerosis: A randomised Controlled Clinical Trial
Atherosclerosis(AS) is one of the most common disease sleading tosevere clinical complications. Atherosclerosis forms pockets of fat and lipid deposit sunder the mucous tunic of blood vessels, which cause progressive vasoconstriction until total luminal blockage occurs. 1Many "Civilization diseases" such as coronary artery disease (CAD), arterial hypertension (AH), diabetes mellitus (DM), psoriasis, gout, and such conditions as hyper lipidemia, hyperglycemia, dyslipidemia, hyperinsulinemia, hypercortisolemia, hyperuricemia, and microalbuminuria are connected with AS development. In these regards, the problem of developing a proven clinical solution for this prevalent disease process is a socially significant one.1,2 During the last 20 years, ASmorbidity has been globally increasing.2,3 Mortality from AS complications, which account for 75-85% of general mortalityinwhole,4 is simultaneously increasing.Thus AS is one of the global problems of conventional medicine.
