An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer

Tapan Behl

An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer

Tapan Behl * § M.Pharm (Gold Medalist), Ph.D.â€‹

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Delhi University

An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer

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Abstract

Colorectal cancer is defined as the cancer of the large intestine or the rectum -thus attributing to some other names related to this cancer such as -bowel cancer or rectal cancer, depending on the site where the tumor has occurred. It mostly begins as a benign tumor with then turns into a carcinoma.Colon cancer and rectal cancer are related in terms of their genetics and thus are studied together as allied tumors. Although some other factors such as age and lifestyle are also concerned with the progression of this cancer, a minority group of people acquire it because of certain genetic predisposition, which is focused upon in this review. Initially it was thought only to occur because of certain mutations in a specific gene called adenomatous polyposis coli (APC) gene which are responsible for initiating the characteristic events which lead to the progression of this tumor.The cases affected by this pathway were called the LOH group. But further researches concluded that there is another different pathway which can lead to the occurrence of this tumor apart from the one briefly stated above.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Tapan Behl. 2014. "An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B4).

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GJMR Volume 14 Issue B4

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

adenomatous polyp APC gene beta-catenin LOH group MSI-positive group

Classification

GJMR-B Classification NLMC Code: QZ 20.5

QZ 40

QZ 52

Submission ReceivedDecember 16, 2013
Peer Review Double Blind
Handling Editor
Accepted January 5, 2014
Published January 15, 2014

Version of record

v1.2

Issue date

September 4, 2014

Language

English

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Article Matrices

Total Score: 144

Country: India

Subject: Global Journal of Medical Research

Authors: Tapan Behl, Ishneet Kaur, Heena Goel, Rajesh K. Pandey (PhD/Dr. count: 0)

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Publish Date: 2014 01, Wed

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