Antioxidant and Cytotoxic Properties of Essential Oils from Native Brazilian Lauraceae Species

Paulo Roberto H. Moreno; Fabiana Lima Silva; Amanda EspÃ­rito Santo; Paola Cristina Branco; LetÃ­cia Veras Costa-Lotufo; Maria ClaÃºdia Marx Young

Antioxidant and Cytotoxic Properties of Essential Oils from Native Brazilian Lauraceae Species

Paulo Roberto H. Moreno *

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Fabiana Lima Silva

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Amanda EspÃrito Santo

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Paola Cristina Branco

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LetÃcia Veras Costa-Lotufo

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Maria ClaÃºdia Marx Young

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Antioxidant and Cytotoxic Properties of Essential Oils from Native Brazilian Lauraceae Species

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Abstract

Analysis of the leaf and stem essential oils from three Brazilian Lauraceae species showed that the major constituent of O. odorifera was safrole (57.1 and 88.5% for leaves and stems, respectively) while for O. indecora leaves the major ones were the α-pinene (12.8%) and β-pinene (12.4%) and β-bisabolol (12.2%) in the stems. For the third species, Persea venosa, the main components of leaf and stem oils were spathulenol (27.8 and 14.7%, respectively) and humulene epoxide II (11.3 and 5.1%, respectively). The bioactivity results indicated that the leaf essential oil from O. indecora was the most active for both radical scavenging activity (IC50=0.142 mg/mL) and cytotoxicity against human tumor cells, with growth inhibitions for the colon tumoral line HCT-116 (100%) and breast cancer cell line MCF-7 (99.2%), at 5 μg/mL concentration. This activity might be related to the presence of α-pinene and β-pinene in the leaf essential oil of O. indecora. However, further studies with the isolated compounds are necessary to fully understand these bioactivites.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Paulo Roberto H. Moreno, Fabiana Lima Silva, Amanda EspÃrito Santo, Paola Cristina Branco, LetÃcia Veras Costa-Lotufo, Maria ClaÃºdia Marx Young. 2020. "Antioxidant and Cytotoxic Properties of Essential Oils from Native Brazilian Lauraceae Species". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 19 (GJMR Volume 19 Issue B3).

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GJMR Volume 19 Issue B3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification NLMC Code: QV 325

Submission ReceivedDecember 15, 2018
Peer Review Double Blind
Handling Editor
Accepted January 1, 2019
Published January 15, 2019

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v1.2

Issue date

January 8, 2020

Language

English

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Article Matrices

Total Score: 150

Country: Brazil

Subject: Global Journal of Medical Research

Authors: Paulo Roberto H. Moreno, Fabiana Lima Silva, Amanda Espírito Santo, Paola Cristina Branco, Letícia Veras Costa-Lotufo, Maria Claúdia Marx Young, Cynthia Murakami, Inês Cordeiro, Sueli A. Nicolau, Leticia Megumi Ishibaru, (PhD/Dr. count: 0)

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