Aqueous extract of Cryptolepis sanguinolenta enhance cytochrome P450 1A isozyme activity in presence of Atesunate

Dr. Ocloo; M. Maxwell; Adjimani

Aqueous extract of Cryptolepis sanguinolenta enhance cytochrome P450 1A isozyme activity in presence of Atesunate

Dr. Ocloo * §

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M. Maxwell

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Adjimani

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aasittie

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University of Ghana

Aqueous extract of Cryptolepis sanguinolenta enhance cytochrome P450 1A isozyme activity in presence of Atesunate

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Abstract

The clinical response to drugs may be affected by the simultaneous administration of other drugs that modify the pharmacokinetics and the disposition profile of medications. Drug metabolism via the cytochrome P450 (CYP) system has emerged as an important determinant in the occurrence of several drug-drug interactions. In our earlier studies, Cryptolepis sanguinolenta was reported to cause sub therapeutic blood levels of dihydroartemisinin of artesunate which could lead to decreased effectiveness, and possibly resistance as a result of herb-drug interactions. However, the role of metabolism in such herb-drug interaction has not been studied.

References

18 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. Ocloo, M. Maxwell, Adjimani, aasittie. 1970. "Aqueous extract of Cryptolepis sanguinolenta enhance cytochrome P450 1A isozyme activity in presence of Atesunate". Global Journal of Medical Research - D: Radiology, Diagnostic GJMR-D Volume 12 (GJMR Volume 12 Issue D5).

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GJMR Volume 12 Issue D5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

artesunate Co-current administration Cryptolepis sanguinolenta cytochrome P450 metabolism

Classification

GJMR-D Classification NLMC Code: QU 135

Submission ReceivedApril 1, 2012
Peer Review Double Blind
Handling Editor
Accepted April 23, 2012
Published May 7, 2012

Version of record

v1.2

Language

English

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Article Matrices

Total Score: 153

Country: Ghana

Subject: Global Journal of Medical Research

Authors: Dr. Ocloo, Augustine., Sakyiamah, M. Maxwell, Adjimani, P. Jonathan, Sittie, A. Archibald (PhD/Dr. count: 1)

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Publish Date: 2012 05, Mon

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Total Views: 7.7K

Total Downloads: 417

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